Jnes is a NES emulator for win32 platforms that uses DirectX for it's hardware interface. It's emulation capabilities include graphics, sound, input devices, and emulating quite a few memory mapping boards found in most USA games and a few popular japanese ones. Jnes boasts a fairly intuitive user interface that makes playing NES a little more enjoyable. One of the coolest features is the included database of Pro-Action-Replay and Game Genie cheats.
For those of you who enjoy netplay Jnes supports Kaillera online gaming.
Previous Versions used the registry but this 1.0 release uses an INI file for settings